PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
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PROTAC Linkers Verwandte Produkte (4098)
Verwandte Produkte (4098)
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PROTAC Linkers Isoform Comparison
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Biotin-PEG2-CH2CH2N3
0 ImagesBiotin-PEG2-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG2-CH2CH2N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Azido-PEG9-amine
0 ImagesAzido-PEG9-amine is a non-cleavable 9 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG9-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG9-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Propargyl-PEG8-acid
0 ImagesPropargyl-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). The ADCs can be used in bacterial infections caused by Gram-negative bacteria. Propargyl-PEG8-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Undecanedioic acid
0 ImagesUndecanedioic acid is an oral activie nndogenous metabolite. Undecanedioic acid is associated with intercellular matrix macromolecules and specifically with elastin.
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2-(4-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperazin-1-yl)acetic acid
0 ImagesArt. -Nr.: HY-W087880CAS. Nr.: 180576-05-0
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Ethyl 3-bromopropanoate
0 ImagesArt. -Nr.: HY-W007449CAS. Nr.: 539-74-2
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tert-Butyl 8-aminooctanoate
0 ImagesArt. -Nr.: HY-W023089CAS. Nr.: 102522-32-7
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tert-Butyl (trans-3-(methylamino)cyclobutyl)carbamate
0 ImagesArt. -Nr.: HY-W259681CAS. Nr.: 2168236-44-8
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Sodium 5-hydroxypentanoate
0 ImagesArt. -Nr.: HY-W055875CAS. Nr.: 37435-69-1
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mPEG45-Epoxide
0 ImagesArt. -Nr.: HY-400145CAS. Nr.: 40349-67-5mPEG45-Epoxide is a PEG derivative containing polyether units. mPEG45-Epoxide can be used to synthesize PROTAC molecules.
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Leukotriene B4-d4
0 ImagesSynonyms: LTB4-d4; 5(S),12(R)-DiHETE-d4Leukotriene B4-d4 is the deuterium labeled Leukotriene B4. Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
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Methyl 4-(2-hydroxyethyl)benzoate
0 ImagesArt. -Nr.: HY-W092298CAS. Nr.: 46190-45-8
